machaondiagnostics.comA Specialized Laboratory and Rare Disease CRO - Machaon Diagnostics

access results contact us 1 800 566 3462 Cro Inquiries Test Information Search for Tests Reference Laboratory Services By Specialty Area Order Forms Clinical Match Policy Specimen Collection & Shipping Machaon Live Clinical Trial Services Rare Disease CRO Central Laboratory Services Subject, Site & Sample Finder Innovative Trial Solutions FAQ Client Support Center Access Results Billing and Payments Secure Messaging Courier Management Job Aids FAQ Education Podcasts By Specialty Area Our Leadership Lab Licenses Test Requisitions & Forms Operational Policies Careers Testimonials Test Information Search for Tests Reference Laboratory Services Coagulation & Platelets Testing Complement Testing Advanced Genetic Testing Sponsored Testing Programs By Specialty Area Coagulation Genetics Complement Rare Disease Immunology Platelet Order Forms Clinical Match Policy Specimen Collection & Shipping Machaon Live Clinical Trial Services Rare Disease CRO Central Laboratory Services Subject, Site & Sample Finder Innovative Trial Solutions FAQ Client Support Center Access Results Billing and Payments Secure Messaging Courier Management Job Aids FAQ Education Podcasts By Specialty Area Coagulation Genetics Complement Rare Disease Immunology Platelet Our Leadership Lab Licenses Test Requisitions & Forms Operational Policies Careers Testimonials access results contact us 1 800 566 3462 Cro Inquiries A Specialized Laboratory and Rare Disease CRO A Specialized Laboratory and Rare Disease CRO Test Directory Order Forms Draw Kits Machaon LIVE Reference Laboratory Services Coagulation & Platelets Testing Complement Testing Advanced Genetics Testing Sponsored Testing Programs Clinical Trial Services Rare Disease CRO Central Laboratory Services Subject, Site & Sample Finder Innovative Trial Solutions That was fast! Faster lab results lead to better patient outcomes. Our mission is "to save more lives with lab tests". We pursue that mission by developing and offering the fastest-in-the-nation lab services. Speed, quality and consistency are the 3 most important pillars of our operation. learn more test directory cro service Delivering results when they matter most. "It’s so great that your lab can do this (HLH genetics) so fast! (June 2021)" Division Head, PedHem/Onc "Thank you! Lab techs are like angels on earth!" Anonymous "Got the results, and just proves how great the service is by you guys!! (November 2021)" Professor, staff nephrologist, Lurie Children’s Hospital of Chicago Chicago, Illinois "We contracted Machaon to set up and run a clinical trial. Mike was a real pleasure to work with, ensuring the trial approvals went through without issue, conducting the trial with a high degree of objectivity and integrity and providing an excellent and useful report. We were quite impressed with how much Machaon worked with us on making sure the best outcomes from the trial showed through." PhD, managing director, nutraceutical firm Hamilton, New Zealand "You saved my patient’s life; you made my day! (HIT testing) (August 2021)" Staff Physician, SF Bay Area Medical Center San Francisco, CA Featured Tests & Panels Activated Protein C – Resistance STAT:48 hours (M-F) Ratio, Clot-based Draw Tube: Blue Top Used to evaluate patients with recurrent venous thrombosis. This is a second generation function assay. While most instances of APC resistance (APCR) are caused by the presence of Factor V Leiden (FVL), APCR may be abnormal with less common Factor V mutations, heparin, oral anticoagulants, lupus anticoagulants or other acquired causes. In cases where APCR is abnormal but FVL testing is normal, sequencing of the Factor V gene may be warranted to detect rare variants. ADAMTS13 Activity STAT:24 hours (7 days a week) ELISA Draw Tube: Blue Top Machaon provides the fastest ADAMTS13 activity and inhibitor testing available in the US. Rapid diagnosis and administration of correct treatment is paramount for TTP and aHUS. This test is diagnostic for Thrombotic Thrombocytopenic Purpura (TTP) when ADAMTS13 Activity levels are below 10%. Consider other Thrombotic Microangiopathies (TMAs), such as atypical Hemolytic Uremic Syndrome (aHUS), for ADAMTS13 Activity levels above 10%. ADAMTS13 Antibody STAT:48 hours (M-F) ELISA Draw Tube: Blue Top Detection of ADAMTS13 specific IgG antibodies may be an indication of a poorer prognosis for patients with abnormally low ADAMTS13 activity levels with a positive inhibitor. ADAMTS13 Gene Sequencing STAT:48 hours (M-F) NGS Draw Tube: Purple Top Congenital Thrombotic Thrombocytopenic Purpura (cTTP) can be rapidly diagnosed with this test. Severe deficiency of ADAMTS13 activity, negative for an inhibitor, represent putative cases of Upshaw-Schulman syndrome; this autosomal recessive inherited form of TTP can be confirmed by gene sequencing. ADAMTS13 Inhibitor STAT:24 hours (7 days a week) ELISA Draw Tube: Blue Top Machaon provides the fastest ADAMTS13 activity and inhibitor testing available in the US. Rapid diagnosis and administration of correct treatment is paramount for TTP and aHUS. This test is diagnostic for Thrombotic Thrombocytopenic Purpura (TTP) when ADAMTS13 Activity levels are below 10%. Consider other Thrombotic Microangiopathies (TMAs), such as atypical Hemolytic Uremic Syndrome (aHUS), for ADAMTS13 Activity levels above 10%. ADAMTS13 Panel STAT:24 hours (7 days a week) ELISA Draw Tube: Blue Top This panel will confirm a diagnosis of TTP, differentiate between inherited and acquired forms of TTP, and provide an assessment of antibody level. ADAMTS13 Activity is diagnostic for Thrombotic Thrombocytopenic Purpura (TTP) when ADAMTS13 Activity levels are below 5-10%. Consider other Thrombotic Microangiopathies (TMAs), such as atypical Hemolytic Uremic Syndrome (aHUS), for ADAMTS13 levels above 10%. Early diagnosis and administration of correct treatment is paramount for TTP and aHUS. Testing for the presence of an inhibitor to ADAMTS13 helps differentiate between inherited and acquired Thrombotic Thrombocytopenic Purpura (TTP), while the ADAMTS13 Antibody assay provides a quantitative assessment of anti-ADAMTS13 antibody level. Rarely, cases of acquired TTP may occur due to antibodies that mediate increased clearance of ADAMTS13 but do not inhibit enzyme activity - these antibodies would be detected in the ADAMTS13 Antibody assay but not the ADAMTS13 Inhibitor assay. aHUS Genetic Panel 3.0 STAT:48 hours (M-F) NGS Draw Tube: Purple Top The clinical presentation of thrombotic microangiopathy (TMA) has been associated with multiple genetic disease including atypical hemolytic uremic syndrome (aHUS), thrombotic thrombocytopenic purpura (TTP), C3 glomerulopathy (C3G, comprising dense deposit disease and C3 glomerulonephritis), congenital B12 deficiency and others. These are difficult-to-diagnose, very sick patients with distinct treatment depending on the nature of the TMA. Accurate, rapid diagnosis is critical. Additionally, patients with the C5 p.Arg885 polymorphism may respond poorly to the current approved therapy, eculizumab. Note: this is the third time (3.0 name designation) we have updated the gene list to reflect the most current understanding of aHUS/TMA in the scientific literature. Alpha-2 Antiplasmin Activity STAT:1 week Chromogenic Draw Tube: Blue Top Alpha-2-antiplasmin is the major physiologic inhibitor of plasmin. Reductions in alpha-2-antiplasmin have been associated with DIC, severe liver disease, malignancy, nephrotic syndrome and following thrombolytic therapy. Alport Syndrome Genetic Panel STAT:48 hours (M-F) NGS Draw Tube: Purple Top Genetics can help confirm a diagnosis of Alport syndrome and may be especially helpful when the clinical phenotype is not clear-cut. Genetics can also inform family planning (for example, does an affected male have X-linked or autosomal Alport and is an affected female heterozygous or homozygous?). Anti-CFH Antibody STAT:48 hours (M-F) ELISA Draw Tube: Red Top Factor H is a regulator of the...